To strengthen regional readiness for infectious disease outbreaks, the World Health Organization (WHO), in collaboration with United Nations Children's Fund (UNICEF), World Food Programme (WFP), Médicins sans frontières (MSF), and the Ghana Armed Forces (GAF), will lead a comprehensive simulation exercise in Ghana from November 11 to 15, 2024. This joint initiative, with participation from Ghana and other selected African countries, will support capacities for public health emergency preparedness and response by deploying innovative rapid-response health facilities capable of effectively managing high-risk outbreaks.