As COVID-19 continues to spread, the higher the chances of more variants emerging. Since the onset of the pandemic, four variants of concern have been identified, with the Delta—first detected in India—being the most transmissible currently and dominant in many countries. In Nigeria, Dr Chikwe Ihekweazu, the Director-General of the Nigeria Centre for Disease Control, explains how the country is responding to the pandemic in the wake of the more infectious variants.