In a bold step toward strengthening public health, Botswana has developed its National Immunization Strategy (NIS) for 2025–2030. Spearheaded by the Ministry of Health's Child Health Division Expanded Program on Immunization (EPI) Unit, with critical support from the World Health Organization (WHO), UNICEF and key stakeholders. The strategy aims to ensure robust protection against vaccine-preventable diseases (VPDs) throughout the life course in alignment with regional and global immunization priorities, such as the Immunization Agenda 2030.